Immunization against influenza by the ocular route
Identifieur interne : 002438 ( Main/Exploration ); précédent : 002437; suivant : 002439Immunization against influenza by the ocular route
Auteurs : G. A. Tannock [Australie] ; Judith A. Paul [Australie] ; R. D. Barry [Australie]Source :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Anaesthetized, Anaesthetized animals, Attenuated, Attenuated vaccines, Comparable immunity, Different methods, Different routes, Dos, Efficient protection, Identical doses, Immunization, Immunizing dose, Immunogenic, Immunogenic response, Immunogenicity, Influenza, Influenza strain, Influenza virus, Inoculated, Inoculation, Intranasal, Intranasal route, Intraocular, Intraocular route, Mass administration, Median, Median doses, Mice inoculated, Nasal turbinates, Ocular, Ocular route, Particular vaccination route, Poor immunogens, Respiratory tract, Same animal model, Same virus, Similar surface antigens, Standard error, Subcutaneous, Subcutaneous routes, Tannock, Tcids0, Turbinate, Unanaesthetized, Unanaesthetized animals, Vaccination, Vaccine, Virus titres.
Abstract
Abstract: The immunogenicity of influenza A strain A/Northern Territory/60/68 for CSL mice when delivered by the ocular, nasal and subcutaneous routes was determined according to the median protective dose, PD50, i.e. the dose of infectious virus required to induce inhibition of multiplication of a standard intranasal challenge dose of 104.5 median tissue-culture-infectious doses (TCID50) of homologous virus three weeks after vaccination (PD50). For mice inoculated by the ocular route, an immunizing dose of 102.89TCID50 per animal was required. For anaesthetized mice vaccinated intranasally and unanaesthetized mice vaccinated subcutaneously these figures are <102.00 and 106.00 TCID50 per animal, respectively. The lower immunogenicity of virus delivered by the ocular route compared with the intranasal route can be correlated with a lowered capacity of ocularly administered virus to replicate in the murine respiratory tract. The immunogenicity of A/Ann Arbor/6/60-ca, administered in two identical doses, was also determined for (a) the intraocular route, (b) the intranasal route with anaesthetized animals and (c) the intranasal route with unanaesthetized animals, using the parental A/Ann Arbor/6/60 as the challenge virus. Two doses were required because ca viruses have been shown to be poor immunogens in the same animal model. The PD50 for the ocular route was 102.83TCID50 per animal compared with 102.71 for the intranasal route using unanaesthetized animals and 101.36 for the intranasal route using anaesthetized animals. Administration of living attenuated vaccine viruses by the ocular route is thus an efficient means of inducing immunity to influenza viruses in the respiratory tract of mice.
Url:
DOI: 10.1016/0264-410X(85)90122-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000F06
- to stream Istex, to step Curation: 000F06
- to stream Istex, to step Checkpoint: 001120
- to stream Main, to step Merge: 002559
- to stream Main, to step Curation: 002438
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Immunization against influenza by the ocular route</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name></author><author><name sortKey="Paul, Judith A" sort="Paul, Judith A" uniqKey="Paul J" first="Judith A." last="Paul">Judith A. Paul</name></author><author><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R. D." last="Barry">R. D. Barry</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DC3E51E11D69ED6F93EAD1FB883CB85D9D65A84B</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1016/0264-410X(85)90122-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-WNQC3TSM-C/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000F06</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F06</idno><idno type="wicri:Area/Istex/Curation">000F06</idno><idno type="wicri:Area/Istex/Checkpoint">001120</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001120</idno><idno type="wicri:doubleKey">0264-410X:1985:Tannock G:immunization:against:influenza</idno><idno type="wicri:Area/Main/Merge">002559</idno><idno type="wicri:Area/Main/Curation">002438</idno><idno type="wicri:Area/Main/Exploration">002438</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Immunization against influenza by the ocular route</title><author><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine, University of Newcastle, New South Wales 2308</wicri:regionArea><wicri:noRegion>New South Wales 2308</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Judith A" sort="Paul, Judith A" uniqKey="Paul J" first="Judith A." last="Paul">Judith A. Paul</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine, University of Newcastle, New South Wales 2308</wicri:regionArea><wicri:noRegion>New South Wales 2308</wicri:noRegion></affiliation></author><author><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R. D." last="Barry">R. D. Barry</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine, University of Newcastle, New South Wales 2308</wicri:regionArea><wicri:noRegion>New South Wales 2308</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="277">277</biblScope><biblScope unit="page" to="280">280</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anaesthetized</term><term>Anaesthetized animals</term><term>Attenuated</term><term>Attenuated vaccines</term><term>Comparable immunity</term><term>Different methods</term><term>Different routes</term><term>Dos</term><term>Efficient protection</term><term>Identical doses</term><term>Immunization</term><term>Immunizing dose</term><term>Immunogenic</term><term>Immunogenic response</term><term>Immunogenicity</term><term>Influenza</term><term>Influenza strain</term><term>Influenza virus</term><term>Inoculated</term><term>Inoculation</term><term>Intranasal</term><term>Intranasal route</term><term>Intraocular</term><term>Intraocular route</term><term>Mass administration</term><term>Median</term><term>Median doses</term><term>Mice inoculated</term><term>Nasal turbinates</term><term>Ocular</term><term>Ocular route</term><term>Particular vaccination route</term><term>Poor immunogens</term><term>Respiratory tract</term><term>Same animal model</term><term>Same virus</term><term>Similar surface antigens</term><term>Standard error</term><term>Subcutaneous</term><term>Subcutaneous routes</term><term>Tannock</term><term>Tcids0</term><term>Turbinate</term><term>Unanaesthetized</term><term>Unanaesthetized animals</term><term>Vaccination</term><term>Vaccine</term><term>Virus titres</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The immunogenicity of influenza A strain A/Northern Territory/60/68 for CSL mice when delivered by the ocular, nasal and subcutaneous routes was determined according to the median protective dose, PD50, i.e. the dose of infectious virus required to induce inhibition of multiplication of a standard intranasal challenge dose of 104.5 median tissue-culture-infectious doses (TCID50) of homologous virus three weeks after vaccination (PD50). For mice inoculated by the ocular route, an immunizing dose of 102.89TCID50 per animal was required. For anaesthetized mice vaccinated intranasally and unanaesthetized mice vaccinated subcutaneously these figures are <102.00 and 106.00 TCID50 per animal, respectively. The lower immunogenicity of virus delivered by the ocular route compared with the intranasal route can be correlated with a lowered capacity of ocularly administered virus to replicate in the murine respiratory tract. The immunogenicity of A/Ann Arbor/6/60-ca, administered in two identical doses, was also determined for (a) the intraocular route, (b) the intranasal route with anaesthetized animals and (c) the intranasal route with unanaesthetized animals, using the parental A/Ann Arbor/6/60 as the challenge virus. Two doses were required because ca viruses have been shown to be poor immunogens in the same animal model. The PD50 for the ocular route was 102.83TCID50 per animal compared with 102.71 for the intranasal route using unanaesthetized animals and 101.36 for the intranasal route using anaesthetized animals. Administration of living attenuated vaccine viruses by the ocular route is thus an efficient means of inducing immunity to influenza viruses in the respiratory tract of mice.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name></noRegion><name sortKey="Barry, R D" sort="Barry, R D" uniqKey="Barry R" first="R. D." last="Barry">R. D. Barry</name><name sortKey="Paul, Judith A" sort="Paul, Judith A" uniqKey="Paul J" first="Judith A." last="Paul">Judith A. Paul</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002438 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002438 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DC3E51E11D69ED6F93EAD1FB883CB85D9D65A84B
|texte= Immunization against influenza by the ocular route
}}
| This area was generated with Dilib version V0.6.33. |  |